Wenjie Zhai Selected Research

Neoplasms (Cancer)

3/2024	Dual targeting of TIGIT and PD-1 with a novel small molecule for cancer immunotherapy.
3/2024	Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy.
3/2024	Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy.
2/2024	Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy.
11/2023	Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy.
1/2023	Identification of a novel small-molecule inhibitor targeting TIM-3 for cancer immunotherapy.
1/2023	Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy.
11/2022	Identification of natural product 3, 5-diiodotyrosine as APOBEC3B inhibitor to prevent somatic mutation accumulation and cancer progression.
5/2022	Intelligent Biomimetic Nanoplatform for Systemic Treatment of Metastatic Triple-Negative Breast Cancer via Enhanced EGFR-Targeted Therapy and Immunotherapy.
4/2022	Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway.

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Wenjie Zhai Research Topics

Disease

30	Neoplasms (Cancer) 03/2024 - 02/2013
2	Esophageal Squamous Cell Carcinoma 11/2022 - 09/2021
2	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 01/2021
1	Colitis 11/2022
1	Colonic Neoplasms (Colon Cancer) 11/2022
1	Triple Negative Breast Neoplasms 05/2022
1	Metabolic Diseases (Metabolic Disease) 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 11/2021
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2018

Drug/Important Bio-Agent (IBA)

12	Peptides (Polypeptides)IBA 03/2024 - 02/2013
10	Immune Checkpoint InhibitorsIBA 03/2024 - 01/2020
4	AntigensIBA 01/2022 - 03/2019
3	Programmed Cell Death 1 ReceptorIBA 03/2024 - 05/2022
3	AntibodiesIBA 03/2024 - 06/2020
3	B7-H1 AntigenIBA 01/2023 - 01/2022
2	LigandsIBA 11/2023 - 01/2019
2	CytokinesIBA 04/2022 - 11/2021
2	AntioxidantsIBA 01/2022 - 01/2021
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2021
2	Cyclic PeptidesIBA 04/2021 - 06/2020
2	Cancer VaccinesIBA 01/2021 - 03/2019
2	Neoplasm Antigens (Tumor Antigens)IBA 03/2019 - 01/2018
1	Amino Acids FDA Link 03/2024
1	Hemin (Panhematin)FDA Link 02/2024
1	Fatty Acids (Saturated Fatty Acids)IBA 11/2023
1	Sialic Acid Binding Immunoglobulin-like LectinsIBA 01/2023
1	AzoxymethaneIBA 11/2022
1	Cytidine DeaminaseIBA 11/2022
1	4-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)IBA 11/2022
1	Dextran SulfateIBA 11/2022
1	Interleukin-15 (Interleukin 15)IBA 11/2022
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 05/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Biomarkers (Surrogate Marker)IBA 11/2021
1	HydrogelsIBA 10/2021
1	N-trimethyl chitosan chlorideIBA 10/2021
1	ChitosanIBA 10/2021
1	Monoclonal AntibodiesIBA 10/2021
1	Antihypertensive Agents (Antihypertensives)IBA 10/2021
1	azelnidipineIBA 10/2021
1	KynurenineIBA 09/2021
1	Tryptophan (L-Tryptophan)FDA Link 09/2021
1	Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)IBA 09/2021
1	Interleukin-8 (Interleukin 8)IBA 09/2021
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 09/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	Protein Subunit VaccinesIBA 01/2021
1	Metformin (Glucophage)FDA LinkGeneric 01/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	HLA-DR Antigens (HLA-DR)IBA 06/2020
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2020
1	NanovaccinesIBA 03/2019
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	VaccinesIBA 01/2017

Therapy/Procedure

20	Immunotherapy 03/2024 - 01/2019
5	Radiotherapy 03/2024 - 03/2019
3	Therapeutics 05/2022 - 01/2018
2	Drug Therapy (Chemotherapy) 03/2019 - 01/2018
1	Chemoprevention 11/2022